|| Associate Professor
||University of Chicago, 2003
Section Editor, NeuroReport
Academic Editor, PLoS One
Guest Associate Editor, Frontiers in Decision Neuroscience
(Special Topic: Dopamine and behavioral flexibility)
Society for Neuroscience
American Psychological Association
The lab focuses on mechanisms of neuroplasticity and learning in the basal ganglia using mouse genetic models and techniques. A primary interest is the role of dopamine in adapting learning and behavior to environmental conditions, with an emphasis on corticostriatal plasticity. The lab takes an integrated approach to the study of behavior and underlying neural mechanism utilizing a range of techniques, including homecage operant paradigms, electrophysiology (in vitro patch clamping) and cyclic voltammetry. We are setting up opto- and pharmaco-genetic tools to bridge behavioral and physiological studies. Applied areas of interest include addiction, Parkinson's disease and obesity. Though the focus of the lab is animal models, we have some human studies underway in parallel with the animal studies, currently focusing on Parkinson's disease.
Augustin, S., Beeler, J.A., McGehee, D.S., and Zhuang, X. (2014). Cyclic AMP and afferent activity govern bidirectional synaptic plasticity in striatopallidal neurons. J Neurosci, v34, pp. 6692-6699.
Koranda, J.L., Cone, J.J., McGehee, D.S., Roitman, M.F., Beeler, J.A. and Zhuang, X (2014). Nicotinic activation scales dynamic range of dopamine release in-vivo. J Neurophysiology, v 111, pp 103-111.
Beeler, J.A., Cools, R., Luciana, M., Ostlund, S.B., Petzinger, G. (2013). A kinder, gentler dopamine . . . highlighting dopamine's role in behavioral flexibility. Editorial introduction to Special Topic on Dopamine and behavioral flexibility, Frontiers in Neuroscience, 8, 4. DOI: 10.3389/fnins.2014.0004.
Beeler, J.A., Jakowec, M., Petzinger, G. (2013). The enemy within: propagation of aberrant corticostriatal plasticity to cortical function in Parkinson's disease. Frontiers in Neurology, v4, DOI=10.3389/fneur.2013.00134.
Beeler, J.A., McDaid, J, Frank, MJ, Alexander, E., Turkson, S., Bernandez, M.S., McGehee, D.S. and Zhuang, X. (2012). A role for dopamine-mediated learning in the pathophysiology and treatment of Parkinson’s disease. Cell Reports, v2(6), p 1747. DOI: 10.1016/j.celrep.2012.11.014.
Beeler, J.A., Frazier, C.R.M., Zhuang, X. (2012). Putting desire on a budget: dopamine and energy expenditure, reconciling reward and resources. Frontiers in Integrative Neuroscience, v. 6:49. DOI: 10.3389/fnint.2012.00049.
Beeler, J.A., McCutcheon, J.E., Cao, Z.F.H., Murakam, M., Roitman, M.F., Zhuang, X. (2012). Taste uncoupled from nutrition fails to sustain reinforcing properties of food, European Journal of Neuroscience, epub ahead of print. DOI: 10.1111/j.1460-9568.2012.08167.
Beeler, J.A., Frazier, C.R.M., Zhuang, X. (2012). Dopaminergic enhancement of local food seeking is under global homeostatic control. European Journal of Neuroscience, v 35, pp.146-159.
Beeler, J.A. (2011). Preservation of function in Parkinson’s disease: what’s learning got to do with it? Brain Research, v 35(1), pp 96-113.
Beeler, J.A., Daw, N., Frazier, C.R.M., Zhuang, X. (2010). Tonic dopamine modulates exploitation of reward learning, Frontiers in Behavioral Neuroscience, 4(170).
Beeler, J.A., Cao, Z.F.H., Khierbek, M.A., Ding, Y., Koranda, J, Kang, U., Zhuang, X. (2010). Dopamine-dependent motor learning: insight into L-dopa's long-duration response. Annals of Neurology, 67(5), p. 639-47.